Map - Magallanes and Antartica Chilena Region (Región de Magallanes y Antártica Chilena)

The Magallanes Region, officially the Magallanes y la Antártica Chilena Region (Región de Magallanes y de la Antártica Chilena), is one of Chile's 16 first order administrative divisions. It is the southernmost, largest, and second least populated region of Chile. It comprises four provinces: Última Esperanza, Magallanes, Tierra del Fuego, and Antártica Chilena.

Magallanes's geographical features include Torres del Paine, Cape Horn, Tierra del Fuego island, and the Strait of Magellan. It also includes the Antarctic territory claimed by Chile. Despite its large area, much of the land in the region is rugged or closed off for sheep farming, and is unsuitable for settlement. 80% of the population lives in the capital Punta Arenas, a major market city and one of the main hubs for Antarctic exploration.

The main economic activities are sheep farming, oil extraction, and tourism. It is also the region with the lowest poverty level in Chile (5.8%); households in Magallanes have the highest income of any region in Chile.

Since 2017, the region has had its own time zone. It uses the summer time for the whole year (UTC−3).

The region contains mountainous peaks and glaciers in the far north, including elements of the Patagonian Ice Sheet. Further south there are other mountain ranges such as the Cerro Toro and numerous surface waters including the Seno Última Esperanza, Eberhard Fjord and Lago Grey. Protected areas include the Torres del Paine National Park and the Cueva del Milodon Natural Monument. At the latter, remains have been discovered of the extinct ground sloth as well as of prehistoric man dating to circa 10,000 BC.

The topography can be divided in four regions: an outer archipelago region (Región Archipielágica) to the west and south, a mountain region in the west and south (Región Cordillerana), a plains region (Región de las Planicies Orientales) in the northeast plus a sub-Andean zone in-between the last two zones (Región Sub-Andina Oriental).